• Adcirca
• Tadalafil

Selective inhibitors of phosphodiesterase 5 (PDE5), which specifically hydrolyzes cGMP, are used to study signaling through the guanylate cyclase activator nitric oxide and to mediate smooth muscle relaxation and vasodilation triggered by cGMP. Tadalafil is a potent inhibitor of PDE5 (IC50 = 1-5 nM) that also blocks the activity of PDE11 (IC50 = 10-33 nM), which hydrolyzes both cAMP and cGMP. The IC50 values for tadalafil against other isoforms of PDE are in the micromolar range. The pharmacokinetics of tadalafil are highlighted by its prolonged duration of effect. PDE5 inhibitors, including tadalafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

1. We can supply sample for testing

2. If the parcel was loss,we will reship for free

3.Payment:WU,TT,Moneygram and Escrow

4.If you want new products,we can synthesis it for your and secret.

5. higher purity with lower price and first -class service

DESCRIPTION

Synonyms

Adcirca

Tadalafil

Selective inhibitors of phosphodiesterase 5 (PDE5), which specifically hydrolyzes cGMP, are used to study signaling through the guanylate cyclase activator nitric oxide and to mediate smooth muscle relaxation and vasodilation triggered by cGMP. Tadalafil is a potent inhibitor of PDE5 (IC50 = 1-5 nM) that also blocks the activity of PDE11 (IC50 = 10-33 nM), which hydrolyzes both cAMP and cGMP. The IC50 values for tadalafil against other isoforms of PDE are in the micromolar range. The pharmacokinetics of tadalafil are highlighted by its prolonged duration of effect. PDE5 inhibitors, including tadalafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

1. We can supply sample for testing
2. If the parcel was loss,we will reship for free
3.Payment:WU,TT,Moneygram and Escrow
4.If you want new products,we can synthesis it for your and secret.

5. higher purity with lower price and first -class service