High purity 99% Sorafenib 284461-73-0 manufacturer CAS NO.284461-73-0 CAS NO.284461-73-0

FOB Price: USD: 100.00-1,000.00 /Gram Get Latest Price
Min.Order: 10 Gram
Payment Terms: D/P,T/T,Other
Available Specifications:
99.5(10-10000)Gram1000/Gram10USD99(10-100)Gram100/Gram10USD

Product Details

Keywords

284461-73-0
Sorafenib
4-AMINO-3,5-DICHLOROPHENACYLBROMIDE

Quick Details

ProName: High purity 99% Sorafenib 284461-73-0 ...
CasNo: 284461-73-0
Appearance: white powder
Application: for research
DeliveryTime: Immediately
PackAge: Aluminum foil bag packaging
Port: SHANGHAI . HONGKONG
ProductionCapacity: 10 Kilogram/Week
Purity: 99.3%
Storage: Low temperature aseptic without light
Transportation: EMS,DHL, FEDEX , HONg Kong express
LimitNum: 10 Gram
Moisture Content: 1
Impurity: 1

Superiority

ProName: High purity 99% Sorafenib 284461-73-0...
CasNo: 284461-73-0
Molecular Formula: C28H24ClF3N4O6S
Appearance: powder
Application: pharmaceutical
DeliveryTime: in stock
PackAge: According client's requirements
Port: any chinese port
ProductionCapacity: 1 Metric Ton/Month
Purity: 98%+
Storage: keep sealed and keep from direct light
Transportation: shipping by DHL,UPS,FEDEX,TNT,EMS,EUB…
LimitNum: 1 Gram

english name:sorafenib

synonyms:bay43-9006;n-[4-chloro-3-(trifluoromethyl)phenyl]-n'-[4-[2-(n-methylcarbamoyl)-4-pyridyloxy]phenyl]urea

specification: 98%

cas no.:284461-73-0

appearance: white crystalline powder

molecular weight: 464.82

molecular formula:c21h16clf3n4o3

items	specifications	results
appearance	off white powder to white powder	off-white powder
identification	h-nmr, ms	complies
water content	< 0.5%	0.06%
loss on drying	<1.0%	0.02%
related impurity by hplc	total impurity ≤1.0% single impurity≤0.3%	0.05% 0.04%
purity (hplc)	≥99%	99.95%

function and application:

sorafenib is a raf kinase inhibitor which suppresses erk phosphorylation. studies indicate that sorafenib induces c-raf phosphorylation

$zhanwei$

at both ser-43 and ser-259. when combined with vitamin k1 phosphorylation is increased at these serine residues. sorafenib also induces the phosphorylation of pka. in addition, sorafenib induces c-met phosphorylation at tyr-1349, which consequently induces pi3k-akt phosphorylation. studies determined that sorafenib inhibits other kinases such as flk-1 (vegfr2), platelet-derived growth factor receptor (pdgfr), flt3, ret, and c-kit.